Factory Free Sample Bulk 99% for nutritional supplement L-Pyroglutamic acid CAS NO.98-79-3

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam.

It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase.

Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.

Nanjing Yuansenthai Biological Technology Co.,Ltd. is a manufacturing company of research chemicals in China,which have been on the market since year 2010.

Headquartered in Nanjing, it has a group of research and development team with many years of rich experience in drug development and rich project management ability.The company has 6500 square meters of GMP standard workshop, Its technology portfolio comprises low temperature,high pressure reactions and continuous processing,Yuansenthai runs its technologies on dedicated and multipurpose equipments on all scales under a quality system based on the process ISO 9001:2015.Equipped with a variety of complete and advanced testing equipment, including LC/MS/MS, DSC, TGA, ICP/MS, GC/MS, HPLC, GC, H-NMR,at the same time, we keep close cooperation with some universities, ensure the smooth progress of pharmaceutical technology development research.

Yuansenthai’s one-site strategy allows reduced decision and communication pathways, thus ensuring rapid and efficient project development as well as clear and transparent communication with customers.We sincerely hope to establish long-term cooperation and common development with our customers.